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The Screw Conveyor was invented in ancient Greece. It was originally used for lifting water. The

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

credit for the invention is attributed to Archimedes. Even today, the basic design concept of t

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e Conveyor Screw remains more or less the same except that power has replaced manual cranking to

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

operate the equipment.

The mechanism of this relatively compact and efficient equipment is quit

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

simple. The Conveyor Screw is fixed in a trough that usually rests horizontally on the floor on

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

saddles and feet. A cover is placed over it. The other parts in the assembly include feed and di

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

charge spouts, shrouds, flange, couplings, bearings and through ends. The only moving part is th

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

screw. It picks up the material that is fed and conveys it to the other end as it rotates. Gate

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

can be used to control the feeding and discharge.

These conveyors normally handle bulk dry mat

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

rials. Since the trough is covered, dust contamination is not a real problem. The screws can be

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

hafted or without shafts. They are available in different sizes. Normally they are used for stra

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ght line or slightly angled movement of materials. For certain applications, multiple screws are

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

also used. The materials from which screws can be manufactured include steel, stainless steel, n

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

lon and Teflon. Sometimes aluminum or brass is also used. Anti-corrosive treatments are normally

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

given for steel screws. Since the screws are wear resistant, maintenance is minimal.

A more ver

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

atile version is the flexible Screw Conveyor, which is also referred to as a spiral conveyor. Th

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

s is normally process-specific and has to be custom-made after taking into consideration various

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

aspects of the operation for which it is used. It can convey materials horizontally, at differen

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

angles and even vertically.

Both fixed screw and flexible types are efficient, and simple to i

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

stall and operate. The running costs are low. Cleaning is easy. They are almost maintenance-free

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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