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As a cleaning service one of the things you will be responsible for is to make sure that you are killing germs and other microorganisms. Germs, disease causing bacteria and viruses can hide in all kinds of

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

nooks and crevices in your buildings - everywhere from toilet seats to doorknobs. And these tiny creatures are not content to stay in one place for long. They catch rides on hands, garbage cans, and cleani

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ng equipment and are then spread throughout the building. Knowing how disinfectants work will help you to choose a suitable disinfectant to control the microorganisms that lurk in your buildings.

So how do

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

disinfectants work? They work by oxidizing the germs, breaking down their cell walls, in other words, disrupting the physical makeup or blocking the energy-yielding or synthetic process of the germs. Becau

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

e different ingredients or combinations of ingredients kill different germs, you need to select a disinfectant that works on the specific germs you are trying to remove. If that is not possible, you should

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

select a broad-spectrum product that works on all the germs that you might face.

There are several types of disinfectants available, but the two categories of disinfectants that a cleaning company needs to

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

know about are:

*Quaternary disinfectants. This type of disinfectant carries a positive charge. The bacteria, viruses and fungi you are trying to remove carry a negative charge. When you clean a surface

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

using a quaternary disinfectant, the cells of the bacteria, viruses and fungi change from a negative to positive charge, which eventually leads to its death.

Quaternary, also referred to as Quats, are typic

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

lly used in low-level sanitization situations. Quaternary disinfectants are odorless, non-staining and non-corrosive to metals. They are fairly non-toxic if used in diluted concentrations.

*Phenolic disin

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

fectants. Phenol and phenolics are the active ingredients in most bottles of common household disinfectants. Phenol is the oldest disinfectant and was originally called carbolic acid. Phenol can be corro

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

sive to skin, so you may want to consider using disinfectants that contain phenolic, which is less corrosive.

Phenolics are very effective at sanitization and disinfection. They are also effective at destr

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

oying several types of bacteria, including the bacteria that causes tuberculosis. Phenolics are fairly expensive to use and they react with some plastic surfaces. To make sure you are using the right dis

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

nfectant and that it is performing as it should pay attention to the following factors:

*Concentration. Mix the disinfectant to the proper dilution rate.

*Contact time. Some disinfectants need to be in con

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

tact with the germs they are trying to kill for specific amount of time. If not left long enough they cannot do their job.

*pH. Certain disinfectants work best under an acidic condition (bleach), while oth

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ers work best under alkaline conditions (quats).

*Temperature. As with pH, bleach works best in cold water and quats work best with warm water.

There are a growing number of products on the market that are

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

specifically designed to limit the spread of germs or effectively remove them from the surfaces people tend to come in contact with. How can you tell what germs a product is intended to kill? Carefully rea

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

the product's label or product fact sheet and look for an EPA number. Commercially sold disinfectants must register their effectiveness claims with the EPA.

As disinfectants are intended to "kill" germs a

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

nd other microorganisms it is important to follow label directions and plan how often to disinfectant surfaces. A disinfectant must be in contact with the germs it is intended to kill. This means you must

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

first clean the surface so it is free of dirt, grease and oil. Then apply the disinfectant let it dwell for the recommended amount of time.

Remember, even though good cleaning removes dirt and many germs,

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

the germs left behind will grow and spread. Using a disinfectant will help to kill the remaining bacteria, viruses and other microorganisms. This will help keep your building clean and its occupants healthy

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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